Human methionine synthase A2756G polymorphism increases susceptibility to prostate cancer
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چکیده
منابع مشابه
The association between methionine synthase A2756G polymorphism and hematological cancer
Background:Numerous studies have focused on the association of methionine synthase (MS) A2756G polymorphism and acute hematological cancer risk. However, the results remain inconsistent. Therefore, a meta-analysis was performed to derive a more precise estimate of the association between them. Methods: This meta-analysis involved 25 articles (26 studies) including 8641 hematological cancer pati...
متن کاملMethionine synthase A2756G polymorphism and lymphoma risk: a meta-analysis.
OBJECTIVE The association between methionine synthase (MS) A2756G polymorphism and lymphoma risk was studied with conflicting results. The present meta-analysis aimed to investigate the overall association between MS A2756G polymorphism and lymphoma risk. MATERIALS AND METHODS We searched PubMed and Embase databases until March 30, 2017, for articles that assessed the association between MS A...
متن کاملMethionine Synthase A2756G Polymorphism and Risk of Colorectal Adenoma and Cancer: Evidence Based on 27 Studies
Methionine synthase (MTR), which plays a central role in maintaining adequate intracellular folate, methionine and normal homocysteine concentrations, was thought to be involved in the development of colorectal cancer (CRC) and colorectal adenoma (CRA) by affecting DNA methylation. However, studies on the association between MTR A2756G polymorphism and CRC/CRA remain conflicting. We conducted a...
متن کاملMethionine synthase polymorphism A2756G is associated with susceptibility for thromboembolic events and altered B vitamin/thiol metabolism.
BACKGROUND AND OBJECTIVES Vitamin B12 dependent methionine synthase (MS) regulates de novo production of methionine from homocysteine (Hcy). Since moderate elevations in Hcy are considered vasculotoxic, we examined a common variant (A2756G-MS) of the gene coding for this enzyme as a risk for thromboembolism. DESIGN AND METHODS We investigated A2756G-MS and folate/thiol status in 51 individual...
متن کاملLack of Association between Methionine Synthase A2756G Polymorphism and Digestive System Cancer Risk: Evidence from 39327 Subjects
BACKGROUND Polymorphisms in genes involved in the metabolism of folate and methyl groups have been implicated with risk of digestive system cancer. Methionine synthase (MTR) plays a central role in folate metabolism, thereby affecting DNA methylation. The association between A2756G polymorphism (rs1805087) in MTR and digestive system cancer susceptibility was inconsistent in previous studies. T...
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ژورنال
عنوان ژورنال: Aging
سال: 2018
ISSN: 1945-4589
DOI: 10.18632/aging.101509